https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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Nanotechnology provides A selection of opportunities to contribute to biology. Right here I will current examples wherever nanofabrication – a chance to make confined buildings with Proportions at will – is used to examine the biophysics of single molecules and cells. I will present some examples from our lab:
You regularly get entangled in discussions about science and religion. You might have also composed several textbooks on the subject. Don’t you believe eventually we will know all the things and that God’s job will likely be over?
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Since 2000, Dekker has shifted the principle aim of his perform toward biophysics where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This modification of field was driven by his fascination to the amazing performing of Organic molecular structures, along with with the long-term viewpoint that lots of appealing discoveries can be expected On this discipline.[five] Latest strains of investigate in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first ever analyze on the dynamics DNA supercoils and the discovery of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is usually that these elements alongside one another make up a residing procedure. The key of reported daily life, I do think, lies while in the interactions, the interaction of Individuals molecules. The massive query about the origin of daily life continues to be unanswered. How did we at any time evolve from straightforward molecules into your very https://www.ceesdekker.net elaborate methods we see currently? We do not know. I need to work on These types of significant, open inquiries.’
Nanopores symbolize a sublime and versatile tool to measure single molecules. We research novel detection modes with solid-state nanopores along with different approaches to measure proteins with nanopores. Tasks encompass the following:
2003, demonstrated the very first biosensors made outside of a carbon nanotube; fixed the framework and mechanism of DNA restore proteins; and discovery of a brand new technique for fabricating good-point out nanopores for DNA translocation
It absolutely was during this period that Dekker carried out analysis on magnetic spin programs and on sounds in superconductors and semiconductors.
In 1993 he was appointed as Affiliate Professor at Delft University of Technological innovation. In the mid-nineties Dekker and his staff achieved accomplishment with the invention of the electronic Houses of carbon nanotubes, the first single-molecule transistor together with other nanoscience.
1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes
2005, discovery on the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational improvements in Mre11/DNA restore complexes; and initially force measurements over a DNA molecule inside of a nanopore
‘I am driven by surprise and inquiries. On a cloth level I come across responses in physics, but I knowledge my deepest joy with God. That religion also drives my science and how I cope with men and women.